Safe Model-Based Multivariable Control of Peritoneal Perfusion

• Published in: IFAC-PapersOnLine Vol. 56; no. 3; pp. 301 - 306
• Main Authors: Moon, Yejin, KadkhodaeiElyaderani, Behzad, Leibowitz, Joshua, Rezaei, Parham, Abdelazim, Eman M., Awad, Morcos, Stachnik, Stephen, Stewart, Shelby, Friedberg, Joseph S., Hahn, Jin-Oh, Fathy, Hosam K.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.01.2023
• Subjects: barrier functions; biomedical devices; perfusion; Safe model reference control; biomedical devices; perfusion; Safe model reference control; barrier functions
• ISSN: 2405-8963; 2405-8963
• DOI: 10.1016/j.ifacol.2023.12.041

This paper examines the control of abdominal perfusion during medical interventions. The goal is to avoid safety risks such as excessive retained fluid volume, tissue damage/trauma, and intra-abdominal hypertension. The paper presents a perfusion system with peristaltic pumps dictating fluid inflow/outflow rates, and uses model-based control to avoid multiple safety risks simultaneously. Specifically, the paper: (i) introduces a discharge efficiency metric reflecting the risk of tissue trauma and/or outflow cavitation; (ii) identifies a dynamic model of discharge efficiency from animal test data; and, (iii) develops a safe perfusion control algorithm based on this model. The algorithm receives three user inputs: a desired inflow rate, a desired perfused volume, and a safety bound on discharge efficiency. The algorithm minimizes the deviation of the commanded inflow/outflow rates from a nonlinear model reference controller, subject to a barrier constraint on discharge efficiency. This furnishes a switching control structure providing convergence to the desired perfusion settings in the absence of outflow occlusion, and operating safely when outflow is occluded, as shown in simulation-based validation studies.