Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model
Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glo...
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Published in | IFAC-PapersOnLine Vol. 55; no. 23; pp. 68 - 73 |
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Format | Journal Article |
Language | English |
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Elsevier Ltd
01.01.2022
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Abstract | Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glomerulus is intercellular communication via the release and uptake of soluble cytokines and growth factors. In diabetic kidney disease, excess collagen deposition alters the mesangial matrix properties, which, we hypothesized diminishes the intercellular signaling between key glomerular cells. To test our hypothesis, we combined established theoretical models of transport to study the impact of pathological deposition on the ability of cells to communicate via intercellular signaling. Our analysis reveals that pathological collagen deposition can enhance rather than diminish the signaling range of the glomerular cells. |
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AbstractList | Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glomerulus is intercellular communication via the release and uptake of soluble cytokines and growth factors. In diabetic kidney disease, excess collagen deposition alters the mesangial matrix properties, which, we hypothesized diminishes the intercellular signaling between key glomerular cells. To test our hypothesis, we combined established theoretical models of transport to study the impact of pathological deposition on the ability of cells to communicate via intercellular signaling. Our analysis reveals that pathological collagen deposition can enhance rather than diminish the signaling range of the glomerular cells. |
Author | Versypt, Ashlee N. Ford Thomas, Haryana Y. |
Author_xml | – sequence: 1 givenname: Haryana Y. surname: Thomas fullname: Thomas, Haryana Y. organization: School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078 USA – sequence: 2 givenname: Ashlee N. Ford surname: Versypt fullname: Versypt, Ashlee N. Ford email: ashleefv@buffalo.edu organization: School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078 USA |
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Cites_doi | 10.3389/fnagi.2018.00245 10.1101/gad.8.16.1875 10.1242/dev.01080 10.1681/ASN.2008050549 10.1073/pnas.94.23.12258 10.1038/sj.icb.7100023 10.1016/j.bpj.2013.06.022 10.1126/scisignal.aaf3998 10.1039/C4LC00037D 10.1021/ma980765f 10.1161/HYPERTENSIONAHA.107.108514 10.1242/dev.125.17.3313 10.2337/diabetes.51.10.3090 10.1161/01.CIR.98.23.2621 10.3389/fmed.2018.00076 10.1038/s41598-020-63443-4 10.1063/1.4874216 10.1073/pnas.1814977115 10.1046/j.1523-1755.2002.00514.x 10.1242/dev.02254 10.1152/ajprenal.00182.2015 10.1089/neu.2008.0719 10.1039/b926849a 10.1002/(SICI)1097-0290(19980720)59:2<214::AID-BIT9>3.0.CO;2-K 10.1016/j.cell.2007.01.004 10.1084/jem.175.5.1413 10.1097/01.ASN.0000065640.77499.D7 10.1371/journal.pcbi.1004206 10.1007/s10439-015-1297-4 10.1101/gad.8.16.1888 |
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Snippet | Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our... |
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Title | Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model |
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