Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model

Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glo...

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Bibliographic Details
Published inIFAC-PapersOnLine Vol. 55; no. 23; pp. 68 - 73
Main Authors Thomas, Haryana Y., Versypt, Ashlee N. Ford
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2022
Subjects
biomedical system modeling
Cellular systems
control of biological systems
kinetic modeling
physiological model
simulation
visualization
visualization
biomedical system modeling
simulation
Cellular systems
control of biological systems
physiological model
kinetic modeling
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Summary:Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glomerulus is intercellular communication via the release and uptake of soluble cytokines and growth factors. In diabetic kidney disease, excess collagen deposition alters the mesangial matrix properties, which, we hypothesized diminishes the intercellular signaling between key glomerular cells. To test our hypothesis, we combined established theoretical models of transport to study the impact of pathological deposition on the ability of cells to communicate via intercellular signaling. Our analysis reveals that pathological collagen deposition can enhance rather than diminish the signaling range of the glomerular cells.
ISSN:2405-8963
2405-8963
DOI:10.1016/j.ifacol.2023.01.017