Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model
Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glo...
Saved in:
Published in | IFAC-PapersOnLine Vol. 55; no. 23; pp. 68 - 73 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.01.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Diabetic kidney disease is a growing health burden. The limited options for treating and preventing diabetic kidney disease are in part due to gaps in our understanding of the progression of diabetic kidney damage and its impacts on cellular function. An important cellular function in the kidney glomerulus is intercellular communication via the release and uptake of soluble cytokines and growth factors. In diabetic kidney disease, excess collagen deposition alters the mesangial matrix properties, which, we hypothesized diminishes the intercellular signaling between key glomerular cells. To test our hypothesis, we combined established theoretical models of transport to study the impact of pathological deposition on the ability of cells to communicate via intercellular signaling. Our analysis reveals that pathological collagen deposition can enhance rather than diminish the signaling range of the glomerular cells. |
---|---|
ISSN: | 2405-8963 2405-8963 |
DOI: | 10.1016/j.ifacol.2023.01.017 |