Model for complex heart rate dynamics in health and diseases

A physiologically motivated, dynamical model of cardiovascular autonomic regulation is shown to be capable of generating long-range correlated and multifractal heart rate. Virtual disease simulations are carried out systematically to account for the disease-induced relative dysfunction of the parasy...

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Bibliographic Details
Published inPhysical review. E, Statistical, nonlinear, and soft matter physics Vol. 72; no. 4 Pt 1; p. 041904
Main Authors Kotani, Kiyoshi, Struzik, Zbigniew R, Takamasu, Kiyoshi, Stanley, H Eugene, Yamamoto, Yoshiharu
Format Journal Article
LanguageEnglish
Published United States 01.10.2005
Subjects
Animals
Baroreflex
Blood Pressure
Computer Simulation
Feedback
Heart - innervation
Heart - physiopathology
Heart Diseases - physiopathology
Heart Rate
Humans
Models, Cardiovascular
Myocardial Contraction
Parasympathetic Nervous System - physiopathology
Sympathetic Nervous System - physiopathology
Vasomotor System - physiopathology
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Summary:A physiologically motivated, dynamical model of cardiovascular autonomic regulation is shown to be capable of generating long-range correlated and multifractal heart rate. Virtual disease simulations are carried out systematically to account for the disease-induced relative dysfunction of the parasympathetic and the sympathetic branches of the autonomic control. Statistical agreement of the simulation results with those of real life data is reached, suggesting the possible use of the model as a state-of-the-art basis for further understanding of the physiological correlates of complex heart rate dynamics.
ISSN:1539-3755
DOI:10.1103/PhysRevE.72.041904