Noninvasive diagnostics of bladder cancer based on analysis of telomerase activity and expression hTERT and hTR coding its subunits

• Published in: Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 8; no. 1; pp. 59 - 68
• Main Authors: Glukhov, A. I., Grigorieva, Y. E., Gordeev, S. A., Vinarov, A. Z., Potoldykova, N. V.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2014; Springer Nature B.V
• Subjects: Biochemistry; Bioorganic Chemistry; Bladder cancer; Chemistry; Chemistry and Materials Science; Gene expression; Medicinal Chemistry; telomerase RNA-subunit (hTR); bladder cancer (BC); diagnositics; noninvasive diagnostics; telomerase; telomerase catalytic subunit (hTERT)

In order to develop noninvasive diagnostics of bladder cancer (BC), telomerase activity has been examined by means the TRAP method (telomerase repeat amplification protocol) in tumor tissue and urine pellet samples taken from patients with bladder cancer. The levels of relative expression of genes e...