Apoptosis and long non-coding RNAs: Focus on their roles in Heart diseases

• Published in: Pathology, research and practice Vol. 251; p. 154889
• Main Author: Al-Masri, Abeer
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2023
• Subjects: Apoptosis; Heart Diseases - genetics; Humans; Myocardial Infarction; Myocytes, Cardiac; RNA, Long Noncoding - genetics; Heart failure; Diabetic cardiomyopathy; Myocardial ischemia; Aging heart; Apoptosis
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.154889

Heart disease is one of the principal death reasons around the world and there is a growing requirement to discover novel healing targets that have the potential to avert or manage these illnesses. On the other hand, apoptosis is a strongly controlled, cell removal procedure that has a crucial part in numerous cardiac problems, such as reperfusion injury, MI (myocardial infarction), consecutive heart failure, and inflammation of myocardium. Completely comprehending the managing procedures of cell death signaling is critical as it is the primary factor that influences patient mortality and morbidity, owing to cardiomyocyte damage. Indeed, the prevention of heart cell death appears to be a viable treatment approach for heart illnesses. According to current researches, a number of long non-coding RNAs cause the heart cells death via different methods that are embroiled in controlling the activity of transcription elements, the pathways that signals transmission within cells, small miRNAs, and the constancy of proteins. When there is too much cell death in the heart, it can cause problems like reduced blood flow, heart damage after restoring blood flow, heart disease in diabetics, and changes in the heart after reduced blood flow. Therefore, studying how lncRNAs control apoptosis could help us find new treatments for heart diseases. In this review, we present recent discoveries about how lncRNAs are involved in causing cell death in different cardiovascular diseases.