The effects of thermally-induced activity in vivo upon the ultrastructure and Na, K and Cl composition of the epithelial cells of sweat glands from patients with cystic fibrosis

The secretory cells of the fundus of sweat glands from cystic fibrosis (CF) patients had higher Na and Cl contents and showed more granule depletion, cellular disruption and dilated intercellular canaliculi than normal. The cells of the coiled duct also had higher cytoplasmic levels of Na and Cl but...

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Published inTissue & cell Vol. 20; no. 5; pp. 691 - 700
Main Authors Wilson, S.M., Elder, H.Y., Sutton, Ann M., Jenkinson, D.McEwan, Cockburn, F., Montgomery, I., McWilliams, S.A., Bovell, D.L.
Format Journal Article
LanguageEnglish
Published Sidcup Elsevier Ltd 1988
Elsevier
Subjects
Abdomen
Biological and medical sciences
Chlorides - analysis
cystic fibrosis
Cystic Fibrosis - metabolism
Cystic Fibrosis - pathology
Electron Probe Microanalysis
Epithelium - analysis
Epithelium - ultrastructure
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hot Temperature
Humans
Male
Medical sciences
Microscopy, Electron
Other diseases. Semiology
Potassium - analysis
Sodium - analysis
Sweat glands
Sweat Glands - analysis
Sweat Glands - ultrastructure
ultrastructure
X-ray microanalysis
X-ray microanalysis
Sweat glands
ultrastructure
cystic fibrosis
Human
Sweat gland
Respiratory disease
Chlorine
Thermal stimulation
Pathology
Mucoviscidosis
Sodium
Ultrastructure
Digestive diseases
Epithelial cell
Potassium
Pancreatic disease
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Summary:The secretory cells of the fundus of sweat glands from cystic fibrosis (CF) patients had higher Na and Cl contents and showed more granule depletion, cellular disruption and dilated intercellular canaliculi than normal. The cells of the coiled duct also had higher cytoplasmic levels of Na and Cl but were structurally normal. Thermal stimulation produced ultrastructural changes in the CF fundus comparable to normal, including further dilatation of the basolateral clefts, but did not induce the marked changes in the coiled duct which normally occur. The elevated Na and fall in K in the fundus and raised Na and Cl in the coiled duct upon activation, were not observed in the CF glands in which no significant changes were detected.
Bibliography:ObjectType-Article-1
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ISSN:0040-8166
1532-3072
DOI:10.1016/0040-8166(88)90016-X