MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness
Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells function as negative regulators. The regulatory influence of γδ T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge a...
Saved in:
Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 13; pp. 8850 - 8855 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
National Acad Sciences
25.06.2002
National Academy of Sciences |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells function as negative regulators. The regulatory influence of γδ T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary γδ T cells. These cells express Vγ4 and depend in their function on the presence of IFN-γ and MHC class I. Moreover, their effect can be demonstrated in the absence of αβ T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response. |
---|---|
Bibliography: | To whom reprint requests may be addressed. E-mail: bornw@njc.org. Edited by James P. Allison, University of California, Berkeley, CA, and approved May 7, 2002 |
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.132519299 |