Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial
This study aimed to evaluate the histologic and cytologic effects of preoperative vaginal estrogen in women with atrophic vaginitis and pelvic organ prolapse. Forty-two women with atrophic vaginitis and stage greater than or equal to 2 prolapse were enrolled in this assessor-blinded randomized contr...
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Published in | Female pelvic medicine & reconstructive surgery Vol. 19; no. 1; p. 34 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.2013
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Subjects | |
Online Access | Get more information |
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Summary: | This study aimed to evaluate the histologic and cytologic effects of preoperative vaginal estrogen in women with atrophic vaginitis and pelvic organ prolapse.
Forty-two women with atrophic vaginitis and stage greater than or equal to 2 prolapse were enrolled in this assessor-blinded randomized controlled trial comparing daily vaginal estrogen cream use for 2 to 12 weeks preoperatively versus no intervention. Data were analyzed using t test and analysis of variance.
Of these 42 women, 22 received treatment and 20 were controls. After a mean 7 (3) weeks of use, the vaginal maturity index increased 15.5% in the treatment group and declined 1.5% in the control group (P < 0.001). The vaginal epithelial thickness was 339 (96) μm in the treatment group compared to 302 (119) μm (P = 0.275) in the controls.
Preoperative vaginal estrogen application for 2 to 12 weeks restores vaginal cytology to premenopausal levels, but does not increase vaginal epithelial thickness in women with prolapse. |
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ISSN: | 2151-8378 |
DOI: | 10.1097/SPV.0b013e318278cc40 |