White Matter Perivascular Spaces on Magnetic Resonance Imaging: Marker of Cerebrovascular Amyloid Burden?

• Published in: Stroke (1970) Vol. 46; no. 6; pp. 1707 - 1709
• Main Authors: Charidimou, Andreas, Hong, Young T, Jäger, Hans R, Fox, Zoe, Aigbirhio, Franklin I, Fryer, Tim D, Menon, David K, Warburton, Elizabeth A, Werring, David J, Baron, Jean-Claude
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.06.2015
• Subjects: Adult; Amyloid beta-Peptides - metabolism; Aniline Compounds - administration & dosage; Biomarkers - metabolism; Cerebral Amyloid Angiopathy - diagnostic imaging; Cerebral Amyloid Angiopathy - metabolism; Cerebral Angiography; Female; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Pilot Projects; Prospective Studies; Thiazoles - administration & dosage; White Matter - diagnostic imaging; White Matter - metabolism; cerebral amyloid angiopathy
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.115.009090

BACKGROUND AND PURPOSE—We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography–based amyloid-β burden across a wide range of cerebrovascular amyloid deposition. METHODS—Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects ≥60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography. CSO-PVS was evaluated on T2-magnetic resonance imaging using a 4-point scale. The association between Pittsburgh compound B and CSO-PVS was assessed in linear regression. RESULTS—In multivariable analyses adjusted for age, microbleeds and white matter hyperintensities, whole cortex Pittsburgh compound B binding was associated with CSO-PVS degree both as continuous (coefficient, 0.11; 95% confidence interval, 0.01–0.22; P=0.040) and as dichotomous variable (coefficient, 0.27; 95% confidence interval, 0.11–0.44; P=0.002). The median Pittsburgh compound B retention was higher in high versus low CSO-PVS degree (P=0.0007). CONCLUSIONS—This pilot study suggests a possible association between cerebrovascular amyloid deposition and CSO-PVS, with potential pathophysiological implications.