Bacterial community dynamics on bats and the implications for pathogen resistance

• Published in: Environmental microbiology Vol. 24; no. 3; pp. 1484 - 1498
• Main Authors: Li, Aoqiang, Li, Zhongle, Dai, Wentao, Parise, Katy L., Leng, Haixia, Jin, Longru, Liu, Sen, Sun, Keping, Hoyt, Joseph R., Feng, Jiang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2022; Wiley Subscription Services, Inc
• Subjects: Animals; Antifungal Agents; Bacteria; Bacteria - genetics; Body condition; Body temperature; Chiroptera; Chiroptera - microbiology; Community structure; Corynebacterium; Fungicides; High resistance; Infections; Microbiological strains; Microbiota; Microbiota - physiology; Microorganisms; Nose - microbiology; Pathogens; Perturbation; Pseudomonas; Rhodococcus; Skin; Skin resistance; Survival; White-nose syndrome
• ISSN: 1462-2912; 1462-2920
• DOI: 10.1111/1462-2920.15754

Summary The bats skin microbiota plays an important role in reducing pathogen infection, including the deadly fungal pathogen Pseudogymnoascus destructans, the causative agent of white‐nose syndrome. However, the dynamic of skin bacterial communities response to environmental perturbations remains poorly described. We characterized skin bacterial community over time and space in Rhinolophus ferrumequinum, a species with high resistance to the infection with P. destructans. We collected environmental covariate data to determine what factors influenced changes in community structure. We observed significant temporal and spatial shifts in the skin bacterial community, which was mainly associated with variation in operational taxonomic units. The skin bacterial community differed by the environmental microbial reservoirs and was most influenced by host body condition, bat roosting temperature and geographic distance between sites, but was not influenced by pathogen infection. Furthermore, the skin microbiota was enriched in particular taxa with antifungal abilities, such as Enterococcus, Burkholderia, Flavobacterium, Pseudomonas, Corynebacterium and Rhodococcus. And specific strains of Pseudomonas, Corynebacterium and Rhodococcus even inhibited P. destructans growth. Our findings provide new insights in characterizing the variation in bacterial communities can inform us about the processes of driving community assembly and predict the host's ability to resist or survive pathogen infection.