2014 Jeffrey M. Hoeg Award Lecture: Transcriptional Control of Monocyte Development

Monocytes and macrophages are key immune cells involved in the early progression of atherosclerosis. Transcription factors that control their development in the bone marrow are important therapeutic targets to control the numbers and functions of these cells in disease. This review highlights what i...

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Published inArteriosclerosis, thrombosis, and vascular biology Vol. 36; no. 9; pp. 1722 - 1733
Main Authors Zhu, Yanfang Peipei, Thomas, Graham D, Hedrick, Catherine C
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 01.09.2016
Subjects
Animals
Bone Marrow Cells - classification
Bone Marrow Cells - immunology
Bone Marrow Cells - physiology
Cell Differentiation
Cellular Microenvironment
Gene Expression Regulation
Genotype
Hematopoiesis, Extramedullary
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Monocytes - classification
Monocytes - immunology
Monocytes - physiology
Myelopoiesis
Phenotype
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
atherosclerosis
microRNAs
monocytes
transcription factors
bone marrow
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Summary:Monocytes and macrophages are key immune cells involved in the early progression of atherosclerosis. Transcription factors that control their development in the bone marrow are important therapeutic targets to control the numbers and functions of these cells in disease. This review highlights what is currently known about the transcription factors that are critical for monocyte development.
Bibliography:ObjectType-Speech/Lecture-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-2
ISSN:1079-5642
1524-4636
1524-4636
DOI:10.1161/ATVBAHA.116.304054