Deep‐frying oil intake and risk of intestinal barrier dysfunction: a systematic review and meta‐analyses

• Published in: International journal of food science & technology Vol. 58; no. 4; pp. 1720 - 1727
• Main Authors: Li, Xue, Liu, Yan‐jun, Liu, Yuan‐fa, Xu, Yong‐jiang
• Format: Journal Article
• Language: English
• Published: Oxford Wiley Subscription Services, Inc 01.04.2023
• Subjects: Colon; Deep‐frying oil; Fatty acids; Frying; immunity; Inflammation; intestinal barrier; Intestinal microflora; Intestine; Lipopolysaccharides; Literature reviews; Meta-analysis; Microbiota; Oil; Permeability; Reviews; short‐chain fatty acids
• ISSN: 0950-5423; 1365-2621
• DOI: 10.1111/ijfs.16343

Summary Deep‐frying oil intake is considered to destroy body health. In this review, a meta‐analysis was performed to assess the effects of deep‐frying oil intake on the risk of intestinal barrier dysfunction. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, a systematic literature search was conducted in PubMed, Embase and Cochrane Central updated till April 2022 (CRD42022326306). A total of nine studies were included. The pooled results revealed that deep‐frying oil intake significantly exaggerated crypt damage of colon [weighted mean difference (WMD) = 4.55; 95% CI: 2.87, 6.24, P < 0.05], increased proinflammatory cytokine expression in plasma and colon tissue, and enhanced intestinal permeability [lipopolysaccharides content (WMD: 10.11 μg mL−1, 95% CI: 7.44, 12.79 μg mL−1, P < 0.05)]. Moreover, deep‐frying oil intake could change the gut microbiota and decrease the content of microbiota‐derived short‐chain fatty acids. In conclusion, our findings provide insights into the effect of deep‐frying oil intake on the intestinal barrier dysfunction. Effects of healthy diet and unhealthy diet on intestinal barrier.