Application of electron microscopy in gastroenterology

Electron microscopy has long been used in research in the fields of life sciences and materials sciences. Transmission and scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX) analyses have also been performed in the field of gastroenterology. Electron microscopy and EDX enabl...

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Published inWorld journal of gastrointestinal pathophysiology Vol. 13; no. 2; pp. 41 - 49
Main Authors Iwamuro, Masaya, Urata, Haruo, Tanaka, Takehiro, Okada, Hiroyuki
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 22.03.2022
Subjects
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Gastrointestinal disease, gastroesophageal reflux disease
Pathogens
Scanning electron microscopy
Energy-dispersive X-ray spectrometry
Transmission electron microscopy
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Summary:Electron microscopy has long been used in research in the fields of life sciences and materials sciences. Transmission and scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX) analyses have also been performed in the field of gastroenterology. Electron microscopy and EDX enable (1) Observation of ultrastructural differences in esophageal epithelial cells in patients with gastroesophageal reflux and eosinophilic esophagitis; (2) Detection of lanthanum deposition in the stomach and duodenum; (3) Ultrastructural and elemental analyses of enteroliths and bezoars; (4) Detection and characterization of microorganisms in the gastrointestinal tract; (5) Diagnosis of gastrointestinal tumors with neuroendocrine differentiation; and (6) Analysis of gold nanoparticles potentially used in endoscopic photodynamic therapy. This review aims to foster a better understanding of electron microscopy applications by reviewing relevant clinical studies, basic research findings, and the state of current research carried out in gastroenterology science.
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Corresponding author: Masaya Iwamuro, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. iwamuromasaya@yahoo.co.jp
Author contributions: Iwamuro M designed the research study and wrote the paper; Urata H and Tanaka T critically reviewed the manuscript for important intellectual content; Okada H approved the manuscript.
ISSN:2150-5330
2150-5330
DOI:10.4291/wjgp.v13.i2.41