Metabolic and immune effects of arginine in postinjury hyperalimentation

Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L)....

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Bibliographic Details
Published inThe journal of trauma Vol. 21; no. 11; p. 970
Main Authors Barbul, A, Sisto, D A, Wasserkrug, H L, Yoshimura, N N, Efron, G
Format Journal Article
LanguageEnglish
Published United States 01.11.1981
Subjects
Amino Acids
Animals
Arginine - pharmacology
Blood
Female
Nitrogen - metabolism
Organ Size
Parenteral Nutrition
Parenteral Nutrition, Total
Rats
Rats, Inbred Strains
Thymus Gland - immunology
Wounds and Injuries - immunology
Wounds and Injuries - metabolism
Wounds and Injuries - therapy
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Summary:Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.
ISSN:0022-5282
DOI:10.1097/00005373-198111000-00011