ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-nitro-2H-indazoles: reactivity and free radical production capacity in the presence of biological systems

Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radica...

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Published inSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 75; no. 1; pp. 375 - 380
Main Authors Folch-Cano, Christian, Olea-Azar, Claudio, Arán, Vicente J, Diaz-Urrutia, Christian
Format Journal Article
LanguageEnglish
Published England 01.01.2010
Subjects
Animals
Anions - chemistry
Electrochemistry - methods
Electron Spin Resonance Spectroscopy - methods
Free Radicals - chemistry
Glutathione - chemistry
Humans
Indazoles - chemistry
Indazoles - pharmacology
Microsomes - drug effects
Molecular Structure
Oxidation-Reduction
Reactive Nitrogen Species - chemistry
Trypanosoma cruzi - cytology
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - metabolism
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Summary:Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radical species generated from nitroindazole derivatives and glutathione (GSH). Moreover, the capacity of intraparasite and intramammals-free radical production, through ESR spectroscopy, was performed.
ISSN:1386-1425
1873-3557
DOI:10.1016/j.saa.2009.10.044