A Rare Case of Metastatic Adrenal Melanoma

• Published in: Curēus (Palo Alto, CA) Vol. 16; no. 7; p. e64182
• Main Authors: Khan, Rohma R, Kahlon, Sunny, Maragh, Jason-Paul, Kimble, Alyssa, Gupta, Shanu
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 09.07.2024; Cureus
• Subjects: Abdomen; Adrenal glands; Biopsy; Bones; Case reports; Dermatology; Dopamine; Hyperglycemia; Immunotherapy; Internal Medicine; Liver; Lungs; Magnetic resonance imaging; Melanoma; Metastasis; Monoclonal antibodies; Oncology; Pain; Patients; Pulmonary embolisms; Side effects; Skin cancer; Spleen; Targeted cancer therapy; Tomography; Urine; flank pain; multidisciplinary tumor board; adult hospital medicine; large adrenal mass; combined nivolumab and ipilimumab therapy; metastatic skin cancer; adrenal melanoma; immunotherapy-related adverse events; pheochromocytoma differential; metastatic melanoma treatment
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.64182

Metastatic melanoma presents a significant clinical challenge, characterized by its aggressive nature and propensity to spread to multiple organ systems. Despite advances in detection and treatment, managing metastatic disease remains complex. Here, we present the case of a 43-year-old male with metastatic melanoma displaying an unusual pattern of involvement, affecting the adrenal gland, liver, spleen, and bones. The diagnostic process was intricate, involving atypical hormonal profiles and a negative BRAF status, necessitating a comprehensive approach for accurate characterization and treatment selection. Immunotherapy demonstrated efficacy but also highlighted the emergence of immune-related adverse events, notably hyperglycemia. This case discusses the heterogeneous nature of metastatic melanoma and underscores the importance of a multidisciplinary approach, close monitoring, and consideration of evolving treatment strategies in its management.