An Improved Assessment Method to Estimate (Poly)phenol Intake in Adults with Chronic Pancreatitis

• Published in: Digestive diseases and sciences Vol. 69; no. 8; pp. 2996 - 3007
• Main Authors: Siprelle, Katharine, Kennedy, Ashley J., Hill, Emily B., Hinton, Alice, Shi, Ni, Madril, Peter, Grainger, Elizabeth, Taylor, Christopher, Nahikian-Nelms, Marcia, Spees, Colleen, Tabung, Fred K., Hart, Phil A., Roberts, Kristen M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Springer Nature B.V
• Subjects: Biochemistry; Gastroenterology; Hepatology; Medicine; Medicine & Public Health; Oncology; Original Article; Pancreatitis; Phenols; Transplant Surgery; Phenolic acid; Dietary pattern; Dietary assessment; Food frequency questionnaire; Lignan; Flavonoid; Phytochemical; Phenol-Explorer; Stilbene
• ISSN: 0163-2116; 1573-2568; 1573-2568
• DOI: 10.1007/s10620-024-08417-6

Background Insights into (poly)phenol exposure represent a modifiable factor that may modulate inflammation in chronic pancreatitis (CP), yet intake is poorly characterized and methods for assessment are underdeveloped. Aims The aims are to develop and test a method for estimating (poly)phenol intake from a 90-day food frequency questionnaire (FFQ) using the Phenol-Explorer database and determine associations with dietary patterns in CP patients versus controls via analysis of previously collected cross-sectional data. Methods Fifty-two CP patients and 48 controls were recruited from an ambulatory clinic at a large, academic institution. To assess the feasibility of the proposed methodology for estimating dietary (poly)phenol exposure, a retrospective analysis of FFQ data was completed. Mann–Whitney U tests were used to compare (poly)phenol intake by group; Spearman correlations and multivariable-adjusted log-linear associations were used to compare (poly)phenol intakes with dietary scores within the sample. Results Estimation of (poly)phenol intake from FFQs was feasible and produced estimates within a range of intake previously reported. Total (poly)phenol intake was significantly lower in CP vs controls (463 vs. 567mg/1000kcal; p  = 0.041). In adjusted analyses, higher total (poly)phenol intake was associated with higher HEI-2015 ( r  = 0.34, p  < 0.001), aMED ( r  = 0.22, p  = 0.007), EDIH ( r  = 0.29, p  < 0.001), and EDIP scores ( r  = 0.35, p  < 0.001), representing higher overall diet quality and lower insulinemic and anti-inflammatory dietary potentials, respectively. Conclusions Using enhanced methods to derive total (poly)phenol intake from an FFQ is feasible. Those with CP have lower total (poly)phenol intake and less favorable dietary pattern indices, thus supporting future tailored dietary intervention studies in this population. Graphical Abstract