A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis

Bioadhesive hydrogels have attracted considerable attention as innovative materials in medical interventions and human–machine interface engineering. Despite significant advances in their application, it remains critical to develop adhesive hydrogels that meet the requirements for biocompatibility,...

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Published inAdvanced healthcare materials Vol. 12; no. 29; p. e2302059
Main Authors Liu, Shengnan, Yu, Qianru, Guo, Rui, Chen, Kuntao, Xia, Jiao, Guo, Zhenhu, He, Lu, Wu, Qian, Liu, Lan, Li, Yunxuan, Zhang, Bozhen, Lu, Lin, Sheng, Xing, Zhu, Jiahua, Zhao, Lingyun, Qi, Hui, Liu, Ke, Yin, Lan
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.11.2023
Subjects
Adhesive strength
Adhesives
Allergic rhinitis
Biocompatibility
Biodegradability
Biodegradation
Biopolymers
Clinical trials
Drug delivery
Gelatin
Hay fever
Hemostasis
Hemostatics
Hydrogels
Medical innovations
Medical materials
Medical wastes
Polyethylene glycol
Rhinitis
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Summary:Bioadhesive hydrogels have attracted considerable attention as innovative materials in medical interventions and human–machine interface engineering. Despite significant advances in their application, it remains critical to develop adhesive hydrogels that meet the requirements for biocompatibility, biodegradability, long‐term strong adhesion, and efficient drug delivery vehicles in moist conditions. A biocompatible, biodegradable, soft, and stretchable hydrogel made from a combination of a biopolymer (unmodified natural gelatin) and stretchable biodegradable poly(ethylene glycol) diacrylate is proposed to achieve durable and tough adhesion and explore its use for convenient and effective intranasal hemostasis and drug administration. Desirable hemostasis efficacy and enhanced therapeutic outcomes for allergic rhinitis are accomplished. Biodegradation enables the spontaneous removal of materials without causing secondary damage and minimizes medical waste. Preliminary trials on human subjects provide an essential foundation for practical applications. This work elucidates material strategies for biodegradable adhesive hydrogels, which are critical to achieving robust material interfaces and advanced drug delivery platforms for novel clinical treatments.
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ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202302059