Cryobiopsy as a Diagnostic Tool in Lung Transplantation: A Case Report

Lung transplantation is an option for patients with advanced lung pathologies. Transbronchial biopsies are routinely conducted during the first year to manage acute rejection episodes, with chronic rejection, particularly bronchiolitis obliterans syndrome, becoming a significant concern thereafter....

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 9; p. e68554
Main Authors Garcia Rueda, Jhon Edwar, Botero Bahamón, Juan David, Cardona Palacio, Alejandro, Campo Campo, Felipe de Jesus, Palacio Mejía, Maria Isabel
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 03.09.2024
Cureus
Subjects
Accuracy
Biopsy
Cardiac/Thoracic/Vascular Surgery
Case reports
Chronic obstructive pulmonary disease
Dysphagia
Extracorporeal membrane oxygenation
Lung transplants
Medical diagnosis
Ostomy
Pathology
Patient safety
Pneumothorax
Tracheotomy
Transplantation
post-lung transplant complications
lung surgery
graft rejection
transplant biopsy
lung biopsy
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Summary:Lung transplantation is an option for patients with advanced lung pathologies. Transbronchial biopsies are routinely conducted during the first year to manage acute rejection episodes, with chronic rejection, particularly bronchiolitis obliterans syndrome, becoming a significant concern thereafter. A 34-year-old patient with a diagnosis of primary ciliary dyskinesia was admitted to the emergency room due to a severe exacerbation that caused mixed respiratory failure. He required intubation and extracorporeal membrane oxygenation (ECMO) support as a bridge to bilateral lung transplantation. Post-transplantation, cryobiopsy was implemented according to local protocol, revealing A3 rejection without microbiological isolations. The implementation of cryobiopsy in lung transplantation proves to be an effective diagnostic strategy, offering enhanced tissue evaluation and improved diagnostic performance in both acute and chronic cellular rejection.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.68554