Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review

Low-intensity pulsed ultrasound (LIPUS) is a developing technology, which has been proven to improve fracture healing process with minimal thermal effects. This noninvasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cel...

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Bibliographic Details
Published inJournal of ultrasound in medicine Vol. 41; no. 3; pp. 547 - 563
Main Authors Palanisamy, Poornima, Alam, Monzurul, Li, Shuai, Chow, Simon K H, Zheng, Yong-Ping
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.03.2022
Subjects
Bone and Bones
Fracture Healing
Fractures, Bone - diagnostic imaging
Fractures, Bone - therapy
Humans
Review
Ultrasonic Therapy
Ultrasonic Waves
ultrasound therapy
fresh fractures
low-intensity pulsed ultrasound
delayed unions
bone healing
nonunions
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Summary:Low-intensity pulsed ultrasound (LIPUS) is a developing technology, which has been proven to improve fracture healing process with minimal thermal effects. This noninvasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cells. Although LIPUS treatment has shown beneficial effects on different bone fracture locations, only very few studies have examined its effects on deeper bones. This study provides an overview on therapeutic ultrasound for fractured bones, possible mechanisms of action, clinical evidences, current limitations, and its future prospects.
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ISSN:0278-4297
1550-9613
1550-9613
DOI:10.1002/jum.15738