Chronic thyroiditis and mitral valve prolapse

Mitral valve prolapse is more prevalent in patients with autoimmune diffuse toxic goiter, suggesting a possible etiologic association. The prevalence of mitral valve prolapse was determined in 75 patients with chronic lymphocytic thyroiditis, another autoimmune thyroid disorder, and in 50 healthy co...

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Bibliographic Details
Published inAnnals of internal medicine Vol. 102; no. 4; p. 479
Main Authors Marks, A D, Channick, B J, Adlin, E V, Kessler, R K, Braitman, L E, Denenberg, B S
Format Journal Article
LanguageEnglish
Published United States 01.04.1985
Subjects
Adult
Aged
Autoantibodies - analysis
Autoimmune Diseases
Continental Population Groups
Echocardiography
Female
Humans
Male
Microsomes - immunology
Middle Aged
Mitral Valve Prolapse - complications
Mitral Valve Prolapse - epidemiology
Mitral Valve Prolapse - immunology
Thyroid Gland - immunology
Thyroiditis, Autoimmune - complications
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Summary:Mitral valve prolapse is more prevalent in patients with autoimmune diffuse toxic goiter, suggesting a possible etiologic association. The prevalence of mitral valve prolapse was determined in 75 patients with chronic lymphocytic thyroiditis, another autoimmune thyroid disorder, and in 50 healthy control subjects. Mitral valve prolapse was found in 31 of 75 (41%) patients with chronic lymphocytic thyroiditis and in 4 of 50 (8%) controls (odds ratio, 8.10; 95% confidence interval, 2.64 to 24.83; p less than 0.0005). The age-race adjusted odds ratio was 9.26 (95% confidence interval, 2.83 to 30.26; p less than 0.0005). No correlation between the prevalence of mitral valve prolapse and the presence of hypothyroidism, serum antithyroid antibodies, or the duration of chronic lymphocytic thyroiditis was found. The prevalence of mitral valve prolapse is substantially increased in patients with the autoimmune thyroid disorders.
ISSN:0003-4819
1539-3704
DOI:10.7326/0003-4819-102-4-479