Species differences in the covalent binding of p-chloro-o-toluidine to DNA

The covalent binding of p-chloro-o-toluidine to hepatic macromolecules was assessed in rats and mice. At all timepoints investigated covalent binding to DNA was most marked in mice, whilst binding to proteins was more pronounced in rats. Two major hydrophobic DNA-adducts were formed in both species....

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Bibliographic Details
Published inArchives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Vol. 9; p. 163
Main Authors Bentley, P, Waechter, F, Bieri, F, Stäubli, W, Muecke, W
Format Journal Article
LanguageEnglish
Published Germany 1986
Subjects
Animals
Carcinogens
DNA - metabolism
In Vitro Techniques
Liver - metabolism
Male
Mice
Neoplasms, Experimental - chemically induced
Proteins - metabolism
Rats
Rats, Inbred Strains
Species Specificity
Toluidines - metabolism
Toluidines - toxicity
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Summary:The covalent binding of p-chloro-o-toluidine to hepatic macromolecules was assessed in rats and mice. At all timepoints investigated covalent binding to DNA was most marked in mice, whilst binding to proteins was more pronounced in rats. Two major hydrophobic DNA-adducts were formed in both species. One of these was formed to a much greater extent (6-30 fold) in mice. Thus, species differences in the metabolism of p-chloro-o-toluidine could account for the fact that mice are more susceptible to the carcinogenic effects of this compound.
ISSN:0171-9750
DOI:10.1007/978-3-642-71248-7_20