Hot-injection synthesis of iron/iron oxide core/shell nanoparticles for T2 contrast enhancement in magnetic resonance imaging

Here we report a new, bench-top synthesis for iron/iron oxide core/shell nanoparticles via the thermal decomposition of Fe(η(5)-C(6)H(3)Me(4))(2). The iron/iron oxide core/shell nanoparticles are superparamagnetic at room temperature and show improved negative contrast in T(2)-weighted MR imaging co...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 32; pp. 9221 - 9223
Main Authors Herman, David A J, Ferguson, Peter, Cheong, Soshan, Hermans, Ian F, Ruck, Ben J, Allan, Kathryn M, Prabakar, Sujay, Spencer, John L, Lendrum, Conrad D, Tilley, Richard D
Format Journal Article
LanguageEnglish
Published England 28.08.2011
Subjects
Contrast Media - chemical synthesis
Contrast Media - chemistry
Ferric Compounds - chemical synthesis
Ferric Compounds - chemistry
Hot Temperature
Imaging
Iron
Iron oxides
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology - methods
Shells
Synthesis
Thermal decomposition
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Summary:Here we report a new, bench-top synthesis for iron/iron oxide core/shell nanoparticles via the thermal decomposition of Fe(η(5)-C(6)H(3)Me(4))(2). The iron/iron oxide core/shell nanoparticles are superparamagnetic at room temperature and show improved negative contrast in T(2)-weighted MR imaging compared to pure iron oxides nanoparticles, and have a transverse relaxivity (r(2)) of 332 mM(-1) s(-1).
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc13416g