The Relationship Between Blood Culture, C-reactive Protein, and Neonatal Sepsis: A Cross-Sectional Study

• Published in: Curēus (Palo Alto, CA) Vol. 16; no. 3; p. e56813
• Main Authors: Ali, Amjed A, Ahmed, Mustafa, Noor, Sufian K, Mustafa, Leena, Ibrahim, Waad, ElAmin, Mohamed, Badri, Hatim M, Natto, Hatim A, Khan, Wahaj A, Osman, Ahmed A
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 24.03.2024; Cureus
• Subjects: Birth weight; Blood; Cesarean section; Cross-sectional studies; Data collection; Ethics; Heart rate; Hypoxia; Infections; Ischemia; Laboratories; Mortality; Newborn babies; Pathology; Patients; Pediatrics; Proteins; Public Health; Questionnaires; Respiratory distress syndrome; Sepsis; Sociodemographics; United States > US; Sudan; neonatal sepsis; newborns; c-reactive protein level; blood culture; pediatrics
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.56813

Background Sepsis is one of the most common causes of morbidity and mortality in newborns. Diagnosis of neonatal sepsis may be difficult because the clinical presentations are often nonspecific. Neonatal sepsis may have an early onset (zero to three days) or a late onset (four days or later). Onset is most rapid in premature neonates. In this study, we aimed to assess the correlation between positive cultures, high C-reactive protein (CRP) levels, and the diagnosis of neonatal sepsis. Methodology This descriptive, prospective, cross-sectional study was undertaken over four months starting from December 15, 2019, to April 15, 2020, in Atbara Teaching Hospital, Sudan. Data were collected from 71 patients. CRP levels were measured, and blood cultures were performed. Results High CRP level >10 mg/L was seen in patients having positive blood culture (55.3%), mainly in preterm babies (CRP >10 mg/dL (61.1%), positive culture (55.6%)) and very low birth weight babies (CRP >10 mg/dL (83.3%) and positive culture (67%)). Conclusions Our findings suggest that is an important cause of neonatal sepsis. CRP was positive in babies mainly with proven sepsis. There is a high correlation between CRP and blood culture in patients with neonatal sepsis which may give access to remodeling the prioritization of the management options in the clinical setting.