Exploring Melatonin's Multifaceted Role in Polycystic Ovary Syndrome Management: A Comprehensive Review

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 11; p. e48929
• Main Authors: Patel, Archan, Dewani, Deepika, Jaiswal, Arpita, Yadav, Pallavi, Reddy, Lucky Srivani
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 16.11.2023; Cureus
• Subjects: Circadian rhythm; Hormones; Infertility; Insulin resistance; Obstetrics/Gynecology; Polycystic ovary syndrome; Sleep; Womens health; sleep disturbances; hormonal imbalance; pcos; melatonin; mood disorders; oxidative stress
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.48929

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder affecting a significant portion of the female population, characterized by hormonal imbalances, oxidative stress, sleep disturbances, and mood disorders. This review explores the multifaceted role of melatonin, a hormone primarily known for regulating circadian rhythms, in PCOS management. Melatonin's potential impact on hormonal balance, oxidative stress, sleep quality, and mood is comprehensively examined. It has been shown to enhance insulin sensitivity, regulate sex hormones, and influence gonadotropins, offering promise in addressing the intricate hormonal imbalances common in PCOS. As a potent antioxidant and anti-inflammatory agent, melatonin mitigates oxidative stress and its associated complications. Its role in improving sleep quality and mood can significantly enhance the psychological well-being and daily functioning of PCOS patients. We discuss the potential implications of melatonin as a complementary or adjunct therapy, alongside existing PCOS treatments, and its significance in improving the overall quality of life for individuals with this syndrome. While further research is needed, melatonin's multifaceted effects promise a brighter future for PCOS patients.