A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectivel...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 7; no. 18; pp. 2920 - 2925
Main Authors Balakrishnan, Biji, Joshi, Nitin, Thorat, Ketan, Kaur, Shahdeep, Chandan, Rajeet, Banerjee, Rinti
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 2019
Subjects
Biopolymers
Breast cancer
Chemotherapy
Doxorubicin
Drug resistance
Gelation
Hydrogels
Miltefosine
Synergistic effect
Toxicity
Tumors
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Summary:Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy.
ISSN:2050-750X
2050-7518
DOI:10.1039/C9TB00454H