A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy
Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectivel...
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Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 7; no. 18; pp. 2920 - 2925 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
2019
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Subjects | |
Online Access | Get full text |
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Summary: | Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy.
In situ
gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy. |
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ISSN: | 2050-750X 2050-7518 |
DOI: | 10.1039/C9TB00454H |