Lymphomatoid Papulosis With DUSP22 Rearrangement in a Patient With a Historical Diagnosis of Primary Cutaneous Anaplastic Large Cell Lymphoma

Lymphomatoid papulosis (LyP) with   rearrangement is an uncommon subtype of lymphomatoid papulosis featured histologically by two distinct patterns of epidermotropic cells, weakly CD30+ small- to medium-sized T-cells and a dermal infiltrate of strongly CD30+ medium- to large-sized T-cells.   rearran...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 8; p. e66022
Main Authors Monika, Fnu, Li, Shuai, Ambler, Emily, Cantu, David, Siref, Andrew
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 02.08.2024
Cureus
Subjects
Biopsy
Cells
Dermatology
Hematology
Immunohistochemistry
Lymphocytes
Lymphoma
Medical diagnosis
Pathology
cd30
alcl
lymphoproliferative disorder
epidermotropism
dusp22 rearrangement
t-cell receptor
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Summary:Lymphomatoid papulosis (LyP) with   rearrangement is an uncommon subtype of lymphomatoid papulosis featured histologically by two distinct patterns of epidermotropic cells, weakly CD30+ small- to medium-sized T-cells and a dermal infiltrate of strongly CD30+ medium- to large-sized T-cells.   rearrangement is detected more frequently in anaplastic large cell lymphoma (ALCL) than in LyP. Primary cutaneous anaplastic large cell lymphoma (pcALCL) cases can also show a similar biphasic CD30 staining pattern. LyP with   rearrangement has a more indolent clinical course than pcALCL and is more likely to regress without treatment. Herein, we report a unique case of LyP with   rearrangement diagnosed in an 81-year-old female with a historical diagnosis of pcALCL, made 20 years prior.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.66022