Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel

Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro tox...

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Published inDyna (Medellín, Colombia) Vol. 89; no. 221; pp. 110 - 120
Main Authors Orozco-Jiménez, Luz Yaneth, Estrada-Vélez, Verónica, Cuesta-Castro, Diana Paola, Isaza, Juan Pablo, Molina, Francisco, Palacio-B, Jaime, Álvarez-Orozco, María Elena, Ortiz-Trujillo, Isabel
Format Journal Article
LanguageEnglish
Published Bogota Universidad Nacional de Colombia 01.01.2022
Subjects
Air pollution
AIRE protein
Alternative fuels
Biofuels
Diesel
Diesel engines
diesel; particulate matter; organic extraction; genotoxicity; mutagenicity; transcriptomics
diésel
Ethanol
Exposure
extracción orgánica
Fossil fuels
Gene expression
Genes
genotoxicidad
Genotoxicity
Internal combustion engines
material particulado
Morbidity
mutagenicidad y transcriptómicas
Mutagenicity
organic extraction
Particulate emissions
Particulate matter
transcriptomic
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Summary:Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.
ISSN:0012-7353
2346-2183
DOI:10.15446/dyna.v89n221.99394