Analysis of interleukin 7 and platelet-derived growth factor-BB mRNA expression as potential markers in erythema nodosum leprosum

Erythema nodosum leprosum (ENL) is an immunological complication of leprosy characterized by acute inflammation of the skin, nerves, and other organs. Identifying laboratory parameters is important for early diagnosis of leprosy reactions. Various cytokine biomarkers have been examined and only a fe...

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Published inDermatology reports Vol. 16; no. 1; p. 9773
Main Authors Bandjar, Fitri Kadarsih, Tabri, Farida, Muchtar, Sri Vitayani, Hatta, Mochammad, Djawad, Khaeruddin, Ilyas, Farida, Musafirah, Sitti, Massi, Muhammad Nasrum, Bukhari, Agussalim, Zainuddin, Andi Alfian
Format Journal Article
LanguageEnglish
Published Italy PAGEPress Publications, Pavia, Italy 12.03.2024
PAGEPress Publications
Subjects
Erythema nodosum leprosum
interleukin-7
leprosy reaction
Pdgf-Bb
leprosy reaction
erythema nodosum leprosum
interleukin-7
PDGF-BB
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Summary:Erythema nodosum leprosum (ENL) is an immunological complication of leprosy characterized by acute inflammation of the skin, nerves, and other organs. Identifying laboratory parameters is important for early diagnosis of leprosy reactions. Various cytokine biomarkers have been examined and only a few studies have reported on angiogenesis in leprosy. This study aims to understand the pathomechanism of ENL by examining IL-7 and platelet-derived growth factor (PDGF)-BB mRNA expression that can be the development and consideration of new effective therapies to prevent reactions, recurrences, and defects in leprosy. The study used a cross-sectional analytic design. Sampling was done by peripheral blood from the patient and measuring mRNA expression with specific primers RT-PCR. The expression of mRNA IL-7 and PDGF-BB was significantly different between multibasilar patients without reaction and with ENL reaction, where there was an increased expression in ENL patients. This could be used as the development of potential biomarkers in ENL and development of new therapeutic intervention pathways in ENL.
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Availability of data and material: data and materials are available by the authors.
Publisher's note: all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Contributions: the authors contributed equally.
Conflict of interest: the authors declare no potential conflict of interest. Funding: none.
ISSN:2036-7392
2036-7406
DOI:10.4081/dr.2023.9773