Platelet-Associated Antibodies Mediate Protective Autoimmune Response in Schizophrenia

• Published in: Neuropsychobiology Vol. 48; no. 1; pp. 41 - 46
• Main Authors: Sinyakov, Michael S., Kessler, Bezalel, Karp, Leon, Weizman, Abraham, Kessler, Abraham R.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 2003; S. Karger AG
• Subjects: Adult; Adult and adolescent clinical studies; Antibodies - blood; Antibodies - metabolism; Antigens, Human Platelet - blood; Antigens, Human Platelet - immunology; Autoimmunity - immunology; Biological and medical sciences; Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen) / Original Paper; Cluster Analysis; Female; Humans; Male; Medical sciences; Middle Aged; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Regression Analysis; Schizophrenia; Schizophrenia - blood; Schizophrenia - immunology; Spectrophotometry - methods; Autoimmunity; Schizophrenia; Platelet-associated antibodies; Symptom clusters; Psychosis; Human; Platelet; Immune response; Investigation method; Pathophysiology; Brief Psychiatric Rating Scale Overall Gorham; Psychometrics
• ISSN: 0302-282X; 1423-0224
• DOI: 10.1159/000071828

The peripheral blood platelets of schizophrenic patients were isolated, and the level of the platelet-associated antibodies (SPAA) was correlated with the rating scores of discrete schizophrenic symptom clusters evaluated with the Brief Psychiatric Rating Scale. Irrespective of medication and gender, symptom-dependent correlations were established between the SPAA levels and the relevant psychometric scores. The results indicate a heterogeneous origin of schizophrenia and imply the involvement of an autoimmune arm as a predominantly protective immune response.