Effect of coordination to antimony(III) on the antifungal activity of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones

• Published in: Polyhedron Vol. 97; pp. 30 - 38
• Main Authors: Piló, Elisa D.L., Recio-Despaigne, Angel A., Da Silva, Jeferson G., Ferreira, Isabella P., Takahashi, Jaqueline A., Beraldo, Heloisa
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 05.09.2015; Elsevier
• Subjects: Antifungal activity; Antimony(III) complexes; Cell viability; Chemistry; Chemistry, Inorganic & Nuclear; Crystal structures; Crystallography; Hydrazones; Physical Sciences; Science & Technology; Hydrazones; Antimony(III) complexes; Crystal structures; Antifungal activity; Cell viability; ONCOLOGY; COLORIMETRIC ASSAY; COMPLEXES; DERIVATIVES
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2015.05.004

[Sb(2BzpClPh)Cl2], complex (6), was as active as nystatin and twofold more active than the free hydrazone H2BzpClPh against Candida dubliniensis. While H2BzpClPh proved to be inactive against Candida glabrata, complex (6) was more active than miconazole nitrate. [Display omitted] Antimony(III) [Sb(L)Cl2] complexes were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro-phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO2Ph) and 2-acetylpyridine-para-hydroxy-phenylhydrazone (H2AcpOHPh) along with the 2-benzoylpyridine-phenylhydrazone analogs H2BzPh, H2BzpClPh, H2BzpNO2Ph, H2BzpOHPh (HL). [Sb(2BzpClPh)Cl2], complex (6), (IC50=4.91±1.20μmolL−1) was as active as nystatin (IC50=4.44±0.76μmolL−1) and twofold more active than H2BzpClPh (IC50=10.05±0.67μmolL−1) against Candida dubliniensis. While H2BzpClPh proved to be inactive against Candida glabrata, 6 (IC50=10.11±0.64μmolL−1) was more active than miconazole nitrate (IC50=19.50±4.53μmolL−1). Similarly, H2BzpNO2Ph revealed to be inactive against Candida lusitaniae whereas complex [Sb(2BzpNO2Ph)Cl2] (7) (IC50=8.54±2.21μmolL−1) proved to be as active as nystatin (IC50=5.31±0.84μmolL−1).