The Association of Anesthesia Type and Neonatal Outcomes Following Category-1 Cesarean Delivery: A Retrospective Cohort Study

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 3; p. e35910
• Main Authors: Skoog, Carl M, Katzer, Joel F, Wendt, Linder H, Ituk, Unyime
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 08.03.2023; Cureus
• Subjects: Anesthesia; Anesthesiology; Apgar score; Birth weight; Blood pressure; Catheters; Cesarean section; Childbirth & labor; Cohort analysis; Demographics; Drug dosages; Epidural; Fetuses; Gestational age; Intubation; Length of stay; Medical records; Newborn babies; Obstetrics; Obstetrics/Gynecology; Pediatrics; Skin; Umbilical cord; Variables; United Kingdom > UK; epidural anesthesia; apgar score; cesarean delivery; umbilical arterial ph; general anesthesia
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.35910

Objectives Neuraxial anesthesia is the preferred anesthesia technique for cesarean delivery due to a decreased risk of adverse events. However, general anesthesia is often employed during emergent cesarean deliveries to achieve a shorter decision-to-delivery interval. The objective of this study was to determine if the conversion of epidural labor analgesia to surgical anesthesia for a category-1 cesarean delivery is associated with significant neonatal morbidity. Study design This was a retrospective cohort study of all intrapartum category-1 cesarean deliveries performed at an academic tertiary care institution between August 2016 and July 2021. The primary outcome was neonatal morbidity, defined as a composite of neonatal umbilical artery pH < 7.10 and/or 5-min Apgar score < 7, and/or neonatal intensive care unit admission. A multivariate regression analysis was performed to control for the presence of covariates and examine the degree to which they influenced the outcome. Results A total of 185 mother-neonate pairs qualified for inclusion, of which 23 had cesarean delivery under general anesthesia and 162 under epidural anesthesia. There was no significant difference in adverse neonatal outcomes between category-1 cesarean deliveries done under general anesthesia compared to epidural anesthesia (47% vs 35%, p = 0.3). The incidence of umbilical arterial pH < 7.10 was higher in the general anesthesia group compared to the epidural anesthesia group (35% vs 12%, p = 0.018). The multivariate regression model showed that gestational age (OR = 0.63; 95% CI = 0.51-0.75, p = <0.001) and non-reassuring fetal heart trace (OR = 0.18; 95% CI = 0.05-0.58, p = 0.005) were significant predictors of adverse neonatal outcome. Conclusion Our results suggest that the conversion of epidural analgesia to surgical anesthesia for category-1 cesarean delivery in women with a functional labor epidural catheter is not associated with poorer neonatal outcomes.