Primary Low-Grade Peritoneal Serous Carcinoma in a Woman With Psammoma Bodies on Cervicovaginal Cytology

Psammoma bodies in cervicovaginal cytology are a rare finding associated with malignant tumours. A 62-year-old woman was referred to our centre for cytology with nuclear atypia and psammomatous bodies suspicious of malignancy. A complete gynaecological examination was performed including colposcopy...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 5; p. e61056
Main Authors Gonzalez-Bosquet, Eduardo, Avella Marcos, Marta, Rovira, Carlota
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 25.05.2024
Cureus
Subjects
Biopsy
Cellular biology
Cervix
Endometrium
Fallopian tubes
Human papillomavirus
Hysterectomy
Laparoscopy
Magnetic resonance imaging
Obstetrics/Gynecology
Oncology
Ovarian cancer
Patients
Ultrasonic imaging
Uterus
Womens health
laparoscopy
primary peritoneal
psammoma bodies
cervicovaginal cytology
low-grade serous carcinoma
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Summary:Psammoma bodies in cervicovaginal cytology are a rare finding associated with malignant tumours. A 62-year-old woman was referred to our centre for cytology with nuclear atypia and psammomatous bodies suspicious of malignancy. A complete gynaecological examination was performed including colposcopy and ultrasound without significant changes. Hysteroscopy was performed to detect endometrial or endocervical malignancy, endometrial biopsy showed psammoma bodies and atrophic endometrium. Endocervical and cervical biopsies were negative for malignancy. Cervicovaginal cytology and human papillomavirus (HPV) testing were repeated. The result was suggestive of adenocarcinoma and negative for HPV. Laparoscopic hysterectomy with bilateral salpingo-oophorectomy was indicated due to two cervicovaginal cytologies with suspicion of malignancy. Low-grade peritoneal serous carcinoma was diagnosed on the surface of the uterus, ovaries and peritoneum. A second laparoscopy was performed to exclude other pelvic or abdominal lesions, and disease was found in the peritoneum of the pelvis, abdomen and omentum. Adjuvant treatment with six cycles of carboplatin and paclitaxel was indicated. Psammoma bodies in cervicovaginal cytology are a rare clinical situation, and it is mandatory to exclude malignancy.
Bibliography:ObjectType-Case Study-2
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.61056