Inhibitory effect of habu antivenom on fibrinopeptide A release induced by Trimeresurus flavoviridis crude venom

• Published in: Toxicon (Oxford) Vol. 36; no. 4; pp. 687 - 690
• Main Authors: Nakamura, M, Kinjoh, K, Hanashiro, K, Sunagawa, M, Tokeshi, Y, Ueda, T, Kosugi, T
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.1998; Elsevier Science
• Subjects: Animal poisons toxicology. Antivenoms; Animals; Antivenins - pharmacology; Biological and medical sciences; Crotalid Venoms - antagonists & inhibitors; Crotalid Venoms - metabolism; Fibrinogen - metabolism; Fibrinopeptide A - metabolism; Medical sciences; Rabbits; Toxicology; Trimeresurus; Trimeresurus flavoviridis; Blood coagulation; Toxicity; Treatment efficiency; Rabbit; Biological marker; Animal origin; Lagomorpha; Ophidia; Vertebrata; Mammalia; Treatment; Antivenom; Animal; Immunotherapy; Venom; Reptilia; Neutralization
• ISSN: 0041-0101; 1879-3150
• DOI: 10.1016/S0041-0101(97)00049-4

The correlation between the clotting activity of crude venom and concentration of fibrinopeptide A (FPA) released by the crude venom in rabbit plasma was evaluated and expressed as the coefficient of correlation ( r=0.850). The venom-induced FPA release was inhibited by habu antivenom. For such inhibition of FPA release, the correlation between the concentration of habu antivenom ( Y) and that of crude venom ( X) could be expressed by the equation Y=7.115+0.709 X. An absence of venom-induced FPA release in rabbit plasma had suggested that the clotting activity of crude venom could be neutralized by the habu antivenom. It is suggested that determinations of the FPA level in the plasma are effective in providing an indication of the reliability for serotherapy using habu antivenom.