New regulator for energy signaling pathway in plants highlights conservation among species

The "low-energy checkpoint" SNF1-related protein kinases, which are conserved in all eukaryotes, play an important role in cellular metabolic adaptation to differences in energy and oxygen availability. Although the signaling pathways involved in such metabolic adaptations are well underst...

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Bibliographic Details
Published inScience signaling Vol. 3; no. 119; p. jc5
Main Authors Meyer, Anne K, Longin, C Friedrich H, Klose, Christian, Hermann, Andreas
Format Journal Article
LanguageEnglish
Published United States 27.04.2010
Subjects
Energy Metabolism
Genes, Plant
Mutation
Oryza - genetics
Oryza - metabolism
Plants - metabolism
Signal Transduction
Species Specificity
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Summary:The "low-energy checkpoint" SNF1-related protein kinases, which are conserved in all eukaryotes, play an important role in cellular metabolic adaptation to differences in energy and oxygen availability. Although the signaling pathways involved in such metabolic adaptations are well understood in yeast and mammals, they have been poorly understood in plants. A recent study revealed that calcineurin B-like interacting protein kinase 15 (CIPK15) acted as a global regulator of such adaptations, linking the response to O(2) deficiency with the response to carbohydrate starvation in rice (Oryza sativa). Knockout mutants of Nipponbare rice CIPK15 failed to initiate transcription of the glycolytic enzymes alpha-amylase 3 and alcohol dehydrogenase 2, which mediate fermentative metabolism for adenosine triphosphate generation under anaerobic conditions. Targeted manipulation of OsCIPK15 might facilitate rice cultivation and ensure agricultural productivity in regions subject to flooding. Here, we highlight the importance of the energy- and oxygen-sensing pathway indicated by its conservation among different eukaryotic kingdoms.
ISSN:1937-9145
DOI:10.1126/scisignal.3119jc5