Impact of axial ligation on photophysical and photodynamic antimicrobial properties of indium (III) methylsulfanylphenyl porphyrin complexes linked to silver-capped copper ferrite magnetic nanoparticles

• Published in: Polyhedron Vol. 193; pp. 114882 - 114896
• Main Authors: Collen Makola, L., Nyokong, Tebello, Amuhaya, Edith K.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.01.2021; Elsevier
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Crystallography; Magnetic nanoparticles; Photodynamic antimicrobial chemotherapy; Photosensitizer; Physical Sciences; Porphyrins; Science & Technology; Staphylococcus aureus; Photosensitizer; Photodynamic antimicrobial chemotherapy; Staphylococcus aureus; Magnetic nanoparticles; Porphyrins; GOLD; PHOTOSENSITIZERS; CHEMOTHERAPY; THERAPY; FLUORESCENCE; SINGLET OXYGEN; AUREUS; PHTHALOCYANINES
• ISSN: 0277-5387; 1873-3719
• DOI: 10.1016/j.poly.2020.114882

The porphyrin complexes were linked to Ag/CuFe2O4 and used for photodynamic antibacterial chemotherapy against Staphylococcus aureus with log reduction >8 and 0% cell viability for the conjugates. [Display omitted] •Porphyrin complexes are linked to Ag/CuFe2O4 magnetic nanoparticles through S-Ag and B-Ag bonds.•The conjugates and porphyrins alone a used for photodynamic antimicrobial chemotherapy (PACT) against Staphylococcus aureus.•The conjugates gave log reduction >8 with 0% cell viability. Photodynamic antimicrobial chemotherapy (PACT) is a well-known technique used against bacteria that have developed resistance towards antibiotics. We herein report the synthesis, photophysical properties, and PACT activity of 2-hydroxypyridine axial ligated indium 5,10,15,20-tetrakis-(4-phenylmethylthio) porphyrin (3) and quaternized 2-hydroxypyridine axial ligated indium 5,10,15,20-tetrakis-(4-phenylmethylthio) porphyrin (4). The porphyrin complexes (3 and 4) were further linked to oleyamine (OLM)/oleic acid (OLA) capped Ag/CuFe2O4 and also 6-mercapto-1-hexanol functionalized (MCH-Ag/CuFe2O4) nanoparticles through silver - sulphur (Ag-S) and silver-nitrogen (Ag-N); self-assembly. The PACT studies were carried out using Staphylococcus aureus. While all the synthesized porphyrins demonstrated PACT activity, the quaternized complex and its conjugate showed the highest PACT activity with 0% cell viability after irradiation for 25 min, resulting in a log reduction of 8.31.