A Mystery in a Case: Unraveling the Complexity of Bing-Neel Syndrome

Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma characterized by clonal IgM-secreting lymphoplasmacytic cell proliferation. Bing-Neel syndrome (BNS) is a rare complication of WM that results in the infiltration of the central nervous system (CNS) with IgM-secreting...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 7; p. e65042
Main Authors Kotlarz, Payton N, Garcia, Gustavo, Rosario, Manuel, Vargas, Ian, Cai Zhen, Kevin
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 21.07.2024
Cureus
Subjects
Bone marrow
Cerebrospinal fluid
Flow cytometry
Gait
Inhibitor drugs
Internal Medicine
Lymphocytes
Lymphoma
Neurology
Oncology
Patients
Proteins
Targeted cancer therapy
central nervous system metastasis
ibrutinib therapy
waldenström’s macroglobulinemia
bing-neel syndrome
lymphoplasmacytic lymphoma
myd88 mutation
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Summary:Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma characterized by clonal IgM-secreting lymphoplasmacytic cell proliferation. Bing-Neel syndrome (BNS) is a rare complication of WM that results in the infiltration of the central nervous system (CNS) with IgM-secreting lymphoplasmacytic cells. This case study presents a 75-year-old Caucasian male with a history of WM and Agent Orange exposure who ultimately was diagnosed with BNS. This patient posed unique diagnostic challenges as the patient experienced clinical symptoms despite the absence of MRI abnormalities and therapeutic challenges.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.65042