Vitamin D receptor gene rs4334089 polymorphism and Parkinson’s disease in Iranian population

• Published in: Basal ganglia Vol. 6; no. 3; pp. 157 - 160
• Main Authors: Fazeli, Atena, Motallebi, Marzieh, Jamshidi, Javad, Movafagh, Abolfazl, Ghaedi, Hamid, Emamalizadeh, Babak, Kashani, Kaveh, Darvish, Hossein
• Format: Journal Article
• Language: English
• Published: Elsevier GmbH 01.08.2016
• Subjects: Iranian population; Parkinson’s disease; rs4334089; VDR; rs4334089; Iranian population; VDR; Parkinson’s disease
• ISSN: 2210-5336; 2210-5336
• DOI: 10.1016/j.baga.2016.04.001

Parkinson disease (PD) is a neurodegenerative disorder with both contributions of genetic and environmental factors. Protective functions of vitamin D and then vitamin D receptor (VDR) in PD have been declared recently. In this study we investigated the association of VDR rs4334089 gene polymorphism with PD in Iranian population. A total of 1040 subjects including 520 PD patients and 520 unrelated control subjects were recruited in a case-control study. DNA was extracted from peripheral blood of all subjects and rs4334089 polymorphism of VDR was genotyped using PCR-RFLP method. Genotype and allele frequency of rs4334089 were significantly different in PD and control groups and A allele was significantly more frequent in PD patients compared to control group. Our findings suggest that VDR rs4334089 A allele could be a risk factors for PD in Iranian population, although more replication studies are needed to confirm our findings.