Gene therapy of brain cancer by drug delivery nanocapsules
An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with ne...
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| Published in | Matter Vol. 5; no. 8; pp. 2502 - 2504 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
03.08.2022
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| Online Access | Get full text |
| ISSN | 2590-2385 2590-2385 |
| DOI | 10.1016/j.matt.2022.06.038 |
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| Abstract | An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing.
An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing. |
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| AbstractList | An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing.
An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing. |
| Author | Wang, Ran Zhou, Xue-Quan Sun, Wen Bonnet, Sylvestre |
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| Cites_doi | 10.1016/j.ejpb.2015.03.018 10.1002/smll.202101460 10.1126/science.aba8853 10.1038/s41573-020-0090-8 10.1126/scitranslmed.3003601 10.1126/sciadv.abm8011 |
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| References | Mitchell, Billingsley, Haley, Wechsler, Peppas, Langer (bib2) 2021; 20 Walton, Christie, Whittaker, Kleinstiver (bib4) 2020; 368 Yao, Sun, Huang, Dou, Lin, Chen, Ruan, Mao, Yu, Zeng (bib6) 2012; 4 Pérez-Herrero, Fernández-Medarde (bib1) 2015; 93 Zou, Sun, Yang, Zheng, Shimoni, Ruan, Wang, Zhang, Yin, Huang (bib5) 2022; 8 Li, Sun, Li, Luo, He, Sun (bib3) 2021; 17 Yao (10.1016/j.matt.2022.06.038_bib6) 2012; 4 Li (10.1016/j.matt.2022.06.038_bib3) 2021; 17 Walton (10.1016/j.matt.2022.06.038_bib4) 2020; 368 Mitchell (10.1016/j.matt.2022.06.038_bib2) 2021; 20 Zou (10.1016/j.matt.2022.06.038_bib5) 2022; 8 Pérez-Herrero (10.1016/j.matt.2022.06.038_bib1) 2015; 93 |
| References_xml | – volume: 17 start-page: 2101460 year: 2021 ident: bib3 article-title: Small-molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery publication-title: Small – volume: 8 start-page: eabm8011 year: 2022 ident: bib5 article-title: Blood-brain barrier-penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy publication-title: Sci. Adv. – volume: 93 start-page: 52 year: 2015 end-page: 79 ident: bib1 article-title: Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy publication-title: Eur. J. Pharm. Biopharm. – volume: 368 start-page: 290 year: 2020 end-page: 296 ident: bib4 article-title: Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants publication-title: Science – volume: 20 start-page: 101 year: 2021 end-page: 124 ident: bib2 article-title: Engineering precision nanoparticles for drug delivery publication-title: Nat. Rev. Drug Discov. – volume: 4 start-page: 130ra48 year: 2012 ident: bib6 article-title: Targeted delivery of PLK1-siRNA by ScFv suppresses Her2 publication-title: Sci. Transl. Med. – volume: 93 start-page: 52 year: 2015 ident: 10.1016/j.matt.2022.06.038_bib1 article-title: Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2015.03.018 – volume: 17 start-page: 2101460 year: 2021 ident: 10.1016/j.matt.2022.06.038_bib3 article-title: Small-molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery publication-title: Small doi: 10.1002/smll.202101460 – volume: 368 start-page: 290 year: 2020 ident: 10.1016/j.matt.2022.06.038_bib4 article-title: Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants publication-title: Science doi: 10.1126/science.aba8853 – volume: 20 start-page: 101 year: 2021 ident: 10.1016/j.matt.2022.06.038_bib2 article-title: Engineering precision nanoparticles for drug delivery publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-020-0090-8 – volume: 4 start-page: 130ra48 year: 2012 ident: 10.1016/j.matt.2022.06.038_bib6 article-title: Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3003601 – volume: 8 start-page: eabm8011 year: 2022 ident: 10.1016/j.matt.2022.06.038_bib5 article-title: Blood-brain barrier-penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy publication-title: Sci. Adv. doi: 10.1126/sciadv.abm8011 |
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