Gene therapy of brain cancer by drug delivery nanocapsules

An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with ne...

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Bibliographic Details
Published inMatter Vol. 5; no. 8; pp. 2502 - 2504
Main Authors Zhou, Xue-Quan, Wang, Ran, Sun, Wen, Bonnet, Sylvestre
Format Journal Article
LanguageEnglish
Published Elsevier Inc 03.08.2022
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Summary:An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing. An all-in-one polymeric nanocapsule system that combines blood-brain barrier (BBB) crossing and glioblastoma (GBM) dual-targeting peptide, intratumoral degradable disulfide cross-linker, and genome editing tool CRISPR-Cas9 is reported to show exquisite BBB penetration and brain tumor therapy with negligible off-target gene editing.
ISSN:2590-2385
2590-2385
DOI:10.1016/j.matt.2022.06.038