The use of omics in monitoring food gut microbiota interaction outcomes: a review of novel trends and technologies

• Published in: Current opinion in food science Vol. 52; p. 101064
• Main Authors: Farag, Mohamed A, Baky, Mostafa H, von Bergen, Martin, Hegazi, Nesrine M
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2023
• ISSN: 2214-7993; 2214-8000
• DOI: 10.1016/j.cofs.2023.101064

Food-gut microbiome interaction is increasingly recognized for its impact on human nutritional status from early childhood. Increasing studies confirmed that a favored gut microbiome is directly related to the type of consumed diet leading to gut homeostasis. The disruption of such gut-microbiome symbiosis has also been involved in several degenerative health diseases. The monitoring of such complex functional interaction warrants the development of accurate and sensitive analytical tools to monitor such biotransformation capacity of the gut microbiome, especially being various among individuals. Metabolomics fits the requirements as a universal and sensitive analytical tool suited for the detection of 100–1000 metabolites in both targeted and untargeted manner. Our review aims to present a more advanced overview of food-gut microbiome interaction from several perspectives including 1) Recent advances in metabolomics technologies towards food analysis. 2) The monitoring of food-microbiome interaction in biological samples and metabolite recovery. 3) Applications of food-gut interaction towards maximizing its health benefits.