Cascate reactions of progesterone by mycelia and culture broth from marine-derived fungus Aspergillus sydowii CBMAI 935

• Published in: Biocatalysis and agricultural biotechnology Vol. 25; p. 101546
• Main Authors: Cardoso de Paula, Samuel Filipe, Porto, André Luiz Meleiro
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.05.2020
• ISSN: 1878-8181; 1878-8181
• DOI: 10.1016/j.bcab.2020.101546

In this work, bio-oxidation cascate reactions of steroid progesterone were performed using culture broth and mycelia from marine-derived fungus Aspergillus sydowii CBMAI 935. The major products obtained from progesterone by Baeyer-Villiger cascate reactions were testosterone and testololactone. The bio-oxydation reactions were performed in quintuplicate experiments (32 °C, 130 rpm, pH 7.4); after seven days in presence of culture broth, testosterone and testololactone were isolated in 24% and 36% yield, respectively. The testololactone was also isolated from mycelia after seven days in 87% yield. This study involving the cascate reaction of progesterone demonstrated the microbial biotransformation potential for steroidal drugs in environment by marine-derived fungi.