New asymmetric bisthiocarbohydrazones and their mixed ligand nickel(II) complexes: Synthesis, characterization, crystal structure, electrochemical-spectroelectrochemical property, antimicrobial and antioxidant activity

• Published in: Polyhedron Vol. 207; pp. 115372 - 115381
• Main Authors: Kaya, Yeliz, Erçağ, Ayşe, Uğuz, Özlem, Koca, Atıf, Zorlu, Yunus, Hacıoğlu, Mayram, Seher Birteksöz Tan, Ayşe
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.10.2021; Elsevier
• Subjects: Antioxidant; Chemistry; Chemistry, Inorganic & Nuclear; Crystal structure; Crystallography; Isatin thiocarbohydrazone; Nickel(II); Physical Sciences; Science & Technology; CV; Isatin thiocarbohydrazone; Nickel(II); Antioxidant; Crystal structure; THIOCARBOHYDRAZONE; DONOR; ISATIN DERIVATIVES; DNA/PROTEIN-BINDING; NI(II) COMPLEXES; COPPER(II) COMPLEXES; ORGANOTIN(IV) COMPLEXES; ANTIBACTERIAL ACTIVITY; THIOSEMICARBAZONE; METAL-COMPLEXES
• ISSN: 0277-5387; 1873-3719
• DOI: 10.1016/j.poly.2021.115372

New asymmetric isatin bisthiocarbohydrazone ligands and their mixed ligand nickel(II) complexes were synthesized. The synthesized compounds were characterized using analytic and spectroscopic methods. The single crystal structures of one ligand and one complex were resolved by X-ray crystallography. Some of the electrochemical and bioactive properties of the compounds were examined. [Display omitted] New asymmetric isatin bisthiocarbohydrazone ligands were synthesized by the condensation of 3,5-dibromosalicylaldehyde, 3,5-dichlorosalicylaldehyde and 3-bromo-5-chlorosalicylaldehyde with isatin monothiocarbohydrazone. New mixed ligand Ni(II) complexes were synthesized from these ligands using triphenylphosphine (PPh3) as a secondary ligand. The synthesized ligands and complexes were characterized by elemental analysis, FT-IR, 1H NMR, UV–Vis spectroscopy and mass spectrometry techniques, along with conductivity measurements. The ligands bind to the Ni(II) ion as ONS donors. The fourth coordination site is completed by the secondary ligand PPh3. The single crystal structures of one ligand and one complex were also resolved by X-ray crystallography. The electrochemical responses of the ligands and their complexes were determined and the results were evaluated to illustrate the influence of the substitution of different groups on the ligands. While the free ligands only give one oxidation peak, two oxidation peaks are observed for the Ni(II) complexes. Complexation of the ligands with the Ni(II) ion considerably affected the in-situ spectroelectrochemical responses of the ligands. Finally, the in vitro antioxidant and antimicrobial activities of the synthesized compounds were determined.