Molecular mechanisms of human papilloma virus related skin cancers: A review

• Published in: Medicine (Baltimore) Vol. 103; no. 21; p. e38202
• Main Authors: Cozma, Elena-Codruta, Banciu, Laura Mădălina, Celarel, Ana Maria, Soare, Elena, Srichawla, Bahadar S, Kipkorir, Vincent, Găman, Mihnea-Alexandru
• Format: Journal Article
• Language: English
• Published: United States 24.05.2024
• Subjects: Carcinoma, Basal Cell - virology; Carcinoma, Squamous Cell - virology; Human Papillomavirus Viruses; Humans; Melanoma - virology; Papillomaviridae - genetics; Papillomaviridae - pathogenicity; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Skin Neoplasms - virology
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000038202

The human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses which includes small, double-stranded DNA viral agents. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously. However, infection with high-risk viral strains can lead to the development of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva, among others. The role of HPV in carcinogenesis has already been demonstrated for the aforementioned neoplasia. However, regarding skin malignancies, the mechanisms that pinpoint the role played by HPV in their initiation and progression still elude our sight. Until now, the only fully understood mechanism of viral cutaneous oncogenesis is that of human herpes virus 8 infection in Kaposi sarcoma. In the case of HPV infection, however, most data focus on the role that beta strains exhibit in the oncogenesis of cutaneous squamous cell carcinoma (cSCC), along with ultraviolet radiation (UVR) and other environmental or genetic factors. However, recent epidemiological investigations have highlighted that HPV could also trigger the onset of other non-melanocytic, for example, basal cell carcinoma (BCC), and/or melanocytic skin cancers, for example, melanoma. Herein, we provide an overview of the role played by HPV in benign and malignant skin lesions with a particular focus on the main epidemiological, pathophysiological, and molecular aspects delineating the involvement of HPV in skin cancers.