Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole

• Published in: Polyhedron Vol. 170; pp. 537 - 543
• Main Authors: Sadaf, Haseeba, Imtiaz-ud-Din, Fettouhi, Mohammed, Fazal, Atif, Ahmad, Saeed, Farooqi, Bilal Ahmad, Nadeem, Shafqat, Ihsan-ul-Haq, Ahmad, Waqar
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.09.2019
• Subjects: 2-Methylbenzimidazole; Benzimidazole; Biological activity; Palladium(II); X-ray structure; Palladium(II); X-ray structure; Benzimidazole; 2-Methylbenzimidazole; Biological activity
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2019.06.025

Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and the crystal structures of two of them, [Pd(benzimidazole)2Br2]·2DMSO (1) and [Pd(2-methylbenzimidazole)2I2] (5) were determined by X-ray crystallography. In both complexes, the palladium(II) ion is bound to two nitrogen atoms of benzimidazoles and two halide ions at trans positions, adopting a nearly regular square planar geometry. The complexes exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug. [Display omitted] Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)2Br2]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)2I2] (5) were determined by X-ray crystallography, which describe a square planar coordination environment around the Pd(II) ions. Compound 1 crystallizes as a DMSO solvate. The solid state structures of both complexes are stabilized by hydrogen bonding interactions. The biological evaluation of the complexes showed that they exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug.