Contrast enhancement of the liver and blood. Nonionic versus ionic contrast media in the pig

The contrast enhancement of low-osmolality (iohexol) and high-osmolality (diatrizoate) contrast media was compared in 18 pigs following intravenous bolus administration. Liver and blood attenuation and blood sample iodine concentration were measured during the first 3 minutes after injection. Iohexo...

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Bibliographic Details
Published inInvestigative radiology Vol. 20; no. 9; p. 989
Main Authors Jensen, L I, Golman, K, Nyman, U, Dean, P B
Format Journal Article
LanguageEnglish
Published United States 01.12.1985
Subjects
Animals
Aorta
Diatrizoate - analogs & derivatives
Diatrizoate Meglumine
Iodine - blood
Iodine Radioisotopes
Iodobenzoates
Iohexol
Liver - diagnostic imaging
Osmolar Concentration
Swine
Time Factors
Tomography, X-Ray Computed
Triiodobenzoic Acids
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Summary:The contrast enhancement of low-osmolality (iohexol) and high-osmolality (diatrizoate) contrast media was compared in 18 pigs following intravenous bolus administration. Liver and blood attenuation and blood sample iodine concentration were measured during the first 3 minutes after injection. Iohexol produced a significantly higher contrast enhancement in the blood during the period from 0.5 to 3 minutes after injection. Diatrizoate produced a significantly higher contrast enhancement in the liver during the period from 9 to 30 minutes after injection. The greater contrast enhancement of iohexol during the acute phase should be advantageous in dynamic CT.
ISSN:0020-9996
DOI:10.1097/00004424-198512000-00018