Four new chalcones from Erythrina abyssinica

Four new chalcones 1 - 4, named abyssinones A - D, were isolated from the stem bark of the plant Erythrina abyssinica and their structures were elucidated on the basis of spectroscopic analyses. The compounds 1, 3, and 4 were found to exhibit moderate cytotoxic activity against the human colorectal...

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Published inPlanta medica Vol. 74; no. 4; pp. 422 - 426
Main Authors Cui, L, Thuong, P.T, Lee, H.S, Njamen, D, Mbafor, J.T, Fomum, Z.T, Lee, J, Kim, Y.H, Oh, W.K
Format Journal Article
LanguageEnglish
Published Germany 01.03.2008
Subjects
abyssinone
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
chalcones
Chalcones - chemistry
Chalcones - pharmacology
chemical structure
cultured cells
cytotoxicity
Erythrina
Erythrina - chemistry
Erythrina abyssinica
humans
Molecular Structure
phytochemicals
Plant Bark - chemistry
Plant Stems
spectral analysis
stereochemistry
Uganda
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Summary:Four new chalcones 1 - 4, named abyssinones A - D, were isolated from the stem bark of the plant Erythrina abyssinica and their structures were elucidated on the basis of spectroscopic analyses. The compounds 1, 3, and 4 were found to exhibit moderate cytotoxic activity against the human colorectal cancer cell line (Caco2) with IC (50) values of 13.3, 15.1, and 11.1 microM, respectively.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2008-1034327