Elevated sodium-lithium countertransport: a familial marker of hyperlipidaemia and hypertension?

Erythrocyte sodium-lithium countertransport was measured in normolipidaemic and hyperlipidaemic hypertensive patients, hyperlipidaemic normotensive patients and normal controls. Hypertension and hyperlipidaemia were each independently associated with raised sodium-lithium countertransport (by analys...

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Bibliographic Details
Published inJournal of hypertension Vol. 8; no. 2; p. 139
Main Authors Carr, S J, Thomas, T H, Laker, M F, Wilkinson, R
Format Journal Article
LanguageEnglish
Published England 01.02.1990
Subjects
Antiporters
Body Mass Index
Carrier Proteins - blood
Cholesterol - blood
Erythrocytes - analysis
Female
Humans
Hyperlipidemias - blood
Hyperlipidemias - genetics
Hypertension - blood
Hypertension - genetics
Lithium - blood
Male
Middle Aged
Risk Factors
Sodium - blood
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Summary:Erythrocyte sodium-lithium countertransport was measured in normolipidaemic and hyperlipidaemic hypertensive patients, hyperlipidaemic normotensive patients and normal controls. Hypertension and hyperlipidaemia were each independently associated with raised sodium-lithium countertransport (by analysis of variance, P less than 0.01 and P less than 0.01). The effects were additive so that hyperlipidaemia could not explain raised sodium-lithium countertransport in hypertension. In hyperlipidaemic hypertensive patients, levels of plasma cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and very-low-density lipoprotein (VLDL) cholesterol were increased, and high-density lipoprotein (HDL) cholesterol was reduced. Of these patients, 73.3% had a known family history of hypertension. Their normotensive first degree relatives were studied, and 48% of these also had raised sodium-lithium countertransport and abnormal plasma lipids (raised cholesterol, triglycerides and LDL cholesterol, and reduced HDL cholesterol). Relatives with normal sodium-lithium countertransport had normal lipids. Therefore, raised sodium-lithium countertransport was associated with the inheritance of both hypertension and hyperlipidaemia, and this could explain why raised sodium-lithium countertransport has been associated with a family history of both hypertension and associated cardiovascular disease.
ISSN:0263-6352
DOI:10.1097/00004872-199002000-00007