Therapy of postoperative stroke: Report of intra-arterial thrombolysis of a hyperacute embolic stroke 5 days following CABG

• Published in: Catheterization and cardiovascular interventions Vol. 54; no. 3; pp. 339 - 341
• Main Authors: Khasani, Sina, Ramee, Stephen R., Felberg, Robert A.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.11.2001; Wiley-Liss
• Subjects: Aged; Biological and medical sciences; cardiopulmonary bypass; complications; Coronary Artery Bypass; hemothorax; Humans; Infarction, Middle Cerebral Artery - drug therapy; Infarction, Middle Cerebral Artery - etiology; Infusions, Intra-Arterial; Male; Medical sciences; Postoperative Complications - drug therapy; Postoperative Complications - etiology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Thrombolytic Therapy; Tissue Plasminogen Activator - therapeutic use; Tomography, X-Ray Computed; Prognosis; Middle cerebral artery; Cardiovascular disease; t-Plasminogen activator; Vascular disease; Aortocoronary; Surgery; Complication; Graft; Recombinant protein; Cerebrovascular disease; Hyperacute; Human; Nervous system diseases; Stroke; Serine endopeptidases; Pathophysiology; Enzyme; Treatment efficiency; Cerebral embolism; Cerebral disorder; Case study; Peptidases; Chemotherapy; Treatment; Bypass; Central nervous system disease; Hydrolases; Fibrinolytic
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/ccd.1295

Intra‐arterial (IA) recombinant tissue plasminogen activator (rt‐PA) is an investigational treatment for acute stroke. We report a case of IA thrombolysis of a hyperacute middle cerebral artery stroke 5 days after coronary artery bypass graft surgery. Despite a serious extracranial bleeding complication (hemothorax), immediate thrombolysis with IA rt‐PA led to near complete resolution of the neurological deficit and a favorable outcome. Cathet Cardiovasc Intervent 2001;54:339–341. © 2001 Wiley‐Liss, Inc.